Starting point 1
Where do chronic and acute brain pathologies meet?
Where it is becoming clear that tauopathies can involve the intersection of multiple chronic pathologies, such as Alzheimer's disease, CTE and Frontotemporal dementias—each contributing different predominant forms of pathological tau, it is less clear how varied synuclein pathologies differ. Efforts are underway to better understand how protein signatures change with the impact of other brain injuries to accelerate or alter the disease process in dementias. Granular protein profiling technologies are helping us to establish signatures of disease burden across different forms of pathological proteins and comorbidities (co-occuring health conditions).
